Application hormonal drugs is prescribed when the balance of hormones in the body is disturbed. This also applies to Euthyrox. When there are problems in the process of producing thyroid hormones, this medicine is prescribed. Some people have to take it for years. And so that an imbalance does not arise, the correct dosage is important. What can an overdose of Euthyrox lead to? And why do insufficient doses of the drug have their consequences? We'll talk about it below.

What is Euthyrox and when is it prescribed?

The drug Euthyrox is available in the form of tablets. white color which basically contain levothyroxine sodium. As auxiliary components, the preparation includes corn starch, gelatin, magnesium stearate, croscarmellose sodium, lactose monohydrate. Euthyrox is a thyroid drug. Thyroid hormonal drugs are used to maintain the level of iodine-containing hormones in the body, for which the thyroid gland is responsible. That is, these tablets are prescribed for thyroid disease.

Eutiroks can be used in different doses. When used in small amounts, it has the following effects on the body:

  • promotes cell renewal and formation,
  • helps tissues and muscle structures to update faster.

When the dosage is slightly higher than the small one, then Euthyrox has the following effect:

  • makes tissues more receptive to oxygen when the latter becomes more necessary for them,
  • helps development and influences active growth,
  • contributes to the process of metabolism of proteins, fats and carbohydrates more actively,
  • stimulates vitality of cardio-vascular system,
  • contributes to the normal functions of the central nervous system.

In large quantities, Euthyrox has the following effects:

  • affects the hormones of the hypothalamus, inhibiting their production,
  • slows down the production of pituitary hormones.

After taking the pills was started, their effect is manifested in a week and a half. The absorption of the drug occurs in the small intestine. Further, it is metabolized in the liver, muscles and brain. A small part of the drug remains unused and leaves the body with the help of the kidneys and along with the bile.

The dosage prescribed by the doctor depends on the type of disease and the condition of the patient. Euthyrox is usually attributed in the presence of certain diseases:

  • lack of hormones in the body thyroid gland, which continues for a long time,
  • benign euthyroid goiter,
  • relapses occurring with goiter,
  • in the form of substitution treatment, if thyroid gland had to remove
  • thyroid oncology,
  • diffuse toxic goiter,
  • when testing the functionality of the thyroid gland.

Help from the drug is quite effective. For example, when a diffuse goiter is being treated, the drug may help reduce or completely disappear after three to six months of using the drug. It prevents an increase in the size of the thyroid gland, and sometimes helps them to decrease.

When can Eutiroks have a negative effect?

Important! The effect of Euthyrox on the body is very serious, so it should not be taken without a medical prescription.

There are certain ailments when Euthyrox should not be drunk. It is contraindicated in such cases:

  • hypersensitivity to levothyroxine sodium or other components of the tablets,
  • untreated increase in thyroid hormones in the body,
  • pituitary insufficiency of an untreated nature,
  • adrenal insufficiency,
  • acute myocardium,
  • myocardial infarction,
  • acute inflammation of all cardiac layers.

Contraindications to the use of Euthyrox suggest that this drug can aggravate these diseases. Then his negative influence will exceed the help from him. Very carefully, under the supervision of physicians, it should be taken if the following health problems arise:

  • angina,
  • coronary artery disease,
  • high blood pressure,
  • atherosclerosis,
  • diabetes,
  • diabetes insipidus,
  • cardiac arrhythmias,
  • a long period of lack of hormones produced by the thyroid gland,
  • violations of the absorbent functions of the intestine.

With such contraindications, treatment with Euthyrox is carried out with great care. Also, the use of funds with other medicines must be approached responsibly. After all, Euthyrox interacts with many of them and the effect on the body in this case can have an unpredictable result. Therefore, when prescribing these tablets, inform the doctor about the drugs that you are taking along the way.

Underdose and overdose of Euthyrox

Of all adverse reactions Eutiroks can lead to allergic manifestations, which are recognizable by skin itching and rashes. This happens if the patient has an increased sensitivity to the contents of the remedy. For others side effects may be affected by the wrong dose. In the case of Euthyrox, negative manifestations can appear not only when the dose is exceeded, but also when the amount of the drug used is too small. Its ineffectiveness for the patient has its own symptoms:

  • severe pain in the lower abdomen during menstruation in women,
  • lethargy,
  • headache,
  • drowsiness,
  • apathy,
  • muscle pain,
  • dry skin,
  • skin puffiness,
  • constipation,
  • weight set.

This symptomatology indicates that the body does not have enough hormones produced by the thyroid gland for a long period of time. But an overdose of Euthyrox is characterized by thyrotoxicosis, that is, increased production of these same hormones. This condition is manifested by the following symptoms:

  • abdominal pain in women during menstrual cycle,
  • lack of appetite,
  • vomit,
  • frequent stool,
  • headache,
  • chest pain,
  • rapid heart rate,
  • heart beat disorder,
  • trembling in the body
  • fever,
  • leg cramps,
  • irritability,
  • anxiety,
  • depression,
  • intense sweating,
  • dyspnea,
  • difficulty falling asleep
  • weight loss.

In addition, a high level of thyroid hormones in the body leads to the fact that from the side of the nervous system a person becomes hyperactive, his sleep pattern changes. Heart failure and changes in blood pressure readings occur when an overdose has affected the cardiovascular system. Also, the activity of movements may be disturbed, the signs of osteoporosis may be aggravated. An excess of thyroid hormones leads to problems of the reproductive system, up to infertility.

As soon as you notice any of the symptoms mentioned above, contact your doctor so that he can adjust the dosage or timing of the drug. With minor disruptions in the hormonal system, dose adjustment is quite capable of solving the problem. But when thyroid hormones greatly exceed the norm, then more serious measures are needed. The doctor may prescribe treatment that will eliminate the symptomatic manifestations of an overdose. This is especially true for problems with the heart or blood pressure.

Also, the doctor may cancel the drug for a while to normalize the patient's condition. After all, if a complete cancellation of Euthyrox is prescribed, the consequences may be such that the disease will return to its previous level. Very often, this drug is prescribed for life. Therefore, it can only be canceled for a short period of time. Abrupt cancellation of Euthyrox can have consequences in the form of headache, weakness, drowsiness, apathy, depression.

Conclusion

Hormonal disorders in the body often lead to the fact that doctors prescribe the use of hormones in the form of drugs. Especially when it comes to thyroid problems. After all, this body is responsible for the production of vital substances. Therefore, when thyroid disease is serious enough, hormone therapy may be for life.

One of these drugs responsible for the production of thyroid hormones is Euthyrox, which is made on the basis of levothyroxine sodium. Its effectiveness leads to the normalization of the patient's condition. But if the dose was chosen incorrectly, then negative manifestations are possible. This applies not only to an overdose, but also to an ineffective dose. After all, hormonal balance is a delicate matter. Therefore, always undergo treatment under medical supervision so that the doctor has the opportunity to adjust the use of Euthyrox.

Euthyrox is a synthetic analogue of thyroxine, a thyroid hormone used to treat hypothyroidism. Due to the hormonal action, if the dosage is exceeded, there is a risk of getting an overdose of Euthyrox with unpleasant consequences for the body.

Description of the drug

The drug "Eutiroks" is available in the form of tablets, each of which contains from 25 to 150 mg active substance- levothyroxine sodium, which is a synthetic analogue of the thyroid hormone, as well as additional components. The recommended doses of "Eutiroks" vary depending on the expected therapeutic effect:

  • a high dosage is prescribed to reduce the concentration of a hormone produced by the pituitary gland;
  • medium - increases the activity of the nervous and cardiovascular systems, regulates growth processes and improves tissue respiration;
  • a low dose of Euthyrox is prescribed to stimulate protein and lipid metabolism.

Only a doctor can select the dosage and determine the period of treatment, depending on the individual characteristics of the patient's body and the nature of the course of the disease.

The human body absorbs the drug well. Reviews about the drug are positive: a noticeable therapeutic effect (if the use is regular) is achieved as early as 3-14 days, depending on the disease, and persistent improvements in serious pathologies are observed by patients a few months after the start of the drug. After the tablets are canceled, they stop working after one to two weeks.

Indications for use

"Eutiroks", acting as a natural thyroxine, affects the replenishment of thyroid hormones in various pathological conditions. Indications for the use of the drug are a number of functional disorders of the endocrine system, including:

  • prolonged lack of thyroid hormones (mainly Euthyrox is prescribed for hypothyroidism);
  • chronic negative effect of antibodies that the human body itself produces (autoimmune diseases);
  • an increase in the volume and mass of the gland without violating its functions;
  • recovery after surgery (including surgical treatment oncological diseases);
  • mental retardation and physical development, which is caused by hormonal causes (cretinism);
  • enhanced tissue metabolism and pathological activity of the nervous system;
  • comorbidities treated with drugs that block the functioning of the thyroid gland.

"Eutiroks", the indications for the use of which are quite extensive, is almost universal drug, which treats pathologies of the endocrine system, is used as part of the complex therapy of autoimmune diseases and some conditions of the cardiovascular and nervous systems. It is sometimes necessary to start using the drug during the recovery period after surgical interventions, for preventive and diagnostic purposes (thyroid function test).

How to correctly calculate the dose and how to take the drug in each case? The answer to this question can only be given by the attending physician, based on the results. complex diagnostics the patient's condition. How long the course of treatment will last and whether there are contraindications, the specialist also decides - some patients take the drug throughout their lives, while others need only a certain course.

Side effects of Euthyrox

Unpleasant side effects can occur, first of all, if the necessary dose of Euthyrox is not correctly selected.

Side effects also appear with increased individual sensitivity to one of the elements in the composition of the drug ( allergic reaction), non-compliance with the regimen, or when interacting with some other drugs.

With an insufficiently high dosage, the side effect of the drug is manifested by symptoms of hypothyroidism:

  • weakening of concentration of attention and memory, decrease in working capacity;
  • drowsiness, fatigue and slowness;
  • work disruption digestive system, constipation and nausea;
  • swelling of the face, mucous membranes of the nose and auditory tube(as a result, there is a decrease in hearing and visual acuity).

A patient taking too high dosages may experience the following conditions:

  • pain in the region of the heart and sternum;
  • violations of the frequency and rhythm of contractions of the heart muscle;
  • anxiety, sweating, insomnia, increased anxiety;
  • convulsions and idiopathic tremor (trembling of the trunk or limbs of unknown origin);
  • decreased appetite, weight loss, digestive disorders such as diarrhea and vomiting;
  • menstrual irregularities in women.

Usually, the body reacts quickly to the wrong dosage, which allows you to change the course of therapy in time. Any Negative consequences taking the drug requires a second consultation of a specialist to adjust the treatment regimen and dosage of the drug.

Contraindications to taking medication

The main contraindications are hypersensitivity to the components of the drug, untreated hypothyroidism, thyrotoxicosis and adrenal insufficiency, acute inflammation membranes of the heart or heart muscle, as well as myocardial infarction.

Pregnancy and lactation are not a serious limitation: if a woman starts using Euthyrox before pregnancy, then you can continue taking the drug while waiting for the baby.

Tablets should be taken with caution diabetes, arrhythmias, high blood pressure, or coronary disease hearts. The use of "Eutiroks" in acceptable doses is allowed for the treatment of congenital hypothyroidism in children from birth.

drug overdose

"Eutiroks" is a hormonal drug, therefore, taken in an overdose, it causes a state of hyperfunction of the thyroid gland. The human body usually reacts to hyperthyroidism in the following ways:


In addition, with hyperthyroidism, which causes an overdose of Euthyrox, metabolic processes are disrupted. This provokes weight loss, frequent urination, hair loss, and thinning of the skin or nails.

An incorrectly selected treatment period and an overestimated dosage (or increasing it too quickly) threaten to squeeze ophthalmic nerve which can result in complete loss of vision.

Euthyrox is a hormonal drug necessary for the treatment of thyroid diseases. The drug is an isomer of thyroxine. The result of its action is the acceleration of metabolism and stimulation of growth. muscle tissue. In small doses, Euthyrox helps protein synthesis and enhances the absorption of calcium in the body. The appointment of medium dosages is necessary to accelerate fat, protein and carbohydrate metabolic processes. High doses are prescribed to reduce the production of pituitary hormones and regulate the functioning of the thyroid gland.

The drug is prescribed for patients suffering from euthyroid goiter and hypothyroidism, children with extreme iodine deficiency cretinism, people with oncological problems of the thyroid gland, as well as for prevention in patients who have undergone thyroid surgery.

Euthyrox is also used for the diagnostic test of thyroid suppression.

The main contraindications to taking the drug:

  • individual intolerance to Euthyrox;
  • thyrotoxicosis;
  • myocarditis;
  • myocardial infarction;
  • pancarditis;
  • diabetes;
  • atherosclerosis;
  • severe forms of hypothyroidism;
  • malabsorption syndrome.

How to take Euthyrox

Take the drug in one dose, half an hour before meals, only in the morning. You need to drink Eutiroks with warm boiled water, you can not drink the medicine with tea, coffee or juice. The daily dose is selected by the endocrinologist based on the patient's age, body weight and diagnosis.

As a rule, the drug Euthyrox is taken for life. The dose prescribed for the treatment of goiter and postoperative period from 75 to 200 mcg, with thyrotoxicosis it rises to 100 mcg, oncology treatment requires an increase in dosage to 300 mcg.

Possible side effects

Taking Euthyrox may be complicated by side effects that are manifested by symptoms characteristic of thyrotoxicosis (sweating, insomnia, anxiety, loss of appetite, diarrhea). Overdose is removed by lowering the dose of the drug or plasmapheresis is prescribed. As side effects convulsions and cardiac arrest may occur.

In order for Euthyrox not to cause side effects, it cannot be combined with such drugs:

  • tricyclic antidepressants;
  • insulin;
  • colestipol;
  • aluminum hydroxide;
  • anabolic steroid;
  • Tamoxifen;
  • Asparanginase;
  • estrogen-containing drugs.

Is it possible to take Euthyrox for weight loss

Taking Euthyrox for weight loss without the appointment of an endocrinologist is not recommended. This is a medical drug for the treatment of the thyroid gland, and not a means for removing excess weight.

The instructions do not say that Euthyrox can be used to achieve this effect. This is a hormonal drug and it can give the opposite effect, the woman will begin to recover dramatically. Plus, problems with the heart, thyroid gland, and nervous system can begin.

Self-administration of the drug and overdose gives such side effects:

  • tachycardia;
  • the appearance of excess weight;
  • chest pain;
  • insomnia;
  • violation of the general emotional background;
  • diarrhea;
  • kidney and adrenal problems.

The correct dose of Euthyrox, prescribed by an endocrinologist, allows you to speed up your metabolism and reduce weight. True, reviews about the action of the drug are ambiguous. In some patients, after taking the medicine, lethargy, lethargy and the opposite effect appear, not weight loss, but its increase. A large number of The patient complains of a side effect such as cystitis.

How to take the drug Euthyrox for weight loss correctly

  • The maximum dose is 300mcg per day.
  • The course of taking Euthyrox for weight loss is a month and a half.
  • It is necessary to start taking the drug with small doses, gradually increasing, the dose should also be reduced gradually.
  • If side effects occur, the dose should be reduced.

To reduce the effect of Euthyrox on the heart, one should additionally take β-adrenergic receptor blockers that reduce blood pressure and the frequency of contractions of the heart muscles. Metoprolol is recommended as a blocker.

The drug is prescribed for pregnant women in case of deficiency of thyroid hormones, without which the bearing of the fetus is impossible, this condition is associated with the onset of an autoimmune process. If the patient was diagnosed before pregnancy autoimmune thyroiditis, then bearing a child only exacerbates the situation. If a woman took Euthyrox before conception, then the dose needs to be adjusted upwards. Dosage control is carried out using TSH and T4 tests.

Euthyrox, with all its compensatory properties and the need during the period of bearing a child, also has side effects. If the dose is exceeded:

  • a sharp jump in blood pressure;
  • increased appetite;
  • excess weight;
  • insomnia;
  • sweating;
  • irritability.

With a sharp decrease in the dose, the following symptoms are observed:

  • weakness;
  • apathy;
  • headaches;
  • drowsiness.

Sensitivity to the drug causes problems such as itching and hives.

Properly selected dosage is the basis wellness future mother, so do not neglect the recommendations of endocrinologists.

The drug Euthyrox is prescribed for pregnant women, taking into account the data of laboratory examinations, anamnesis and individual characteristics woman's body. The dose of the drug also depends on the duration of pregnancy, the presence of diseases and the weight of the patient. The drug is taken on an empty stomach in the morning.

The initial dose is 25 mcg per day, it can be maintained throughout the entire period of treatment, and may gradually increase to 250 mcg per day.

Prescribing Euthyrox to nursing mothers

The correct dose of the drug does not harm the mother and child. In order to select the required dosage, the endocrinologist prescribes the necessary laboratory tests to breastfeeding patients.

With a sharp withdrawal of the drug, symptoms of hypothyroidism may develop, affecting the physical well-being of the mother and the production of milk. Abrupt withdrawal of hormones can lead to neurosis or depression.

Milk production is stimulated by certain hormones produced by the thyroid gland, if their hormones are not adequately prescribed by Euthyrox, a synthetic drug that maintains normal hormonal levels of a nursing mother, and therefore sufficient milk production.

The dose of the drug should be physiological, it cannot be exceeded, exceeding the dosage causes drug-induced thyrotoxicosis in the mother and child. This problem is treated by reducing the level of synthetic hormones entering the patient's body.

In order to avoid problems with an overdose, endocrinologists recommend taking tests for T4 and TSH three months after the birth of a child.

This will help to correct the reception of Euthyrox.

Thyroiditis in the postpartum period

After childbirth may develop similar to autoimmune disease, called thyroiditis, this is possible even if there were no problems during pregnancy. In this case, the nursing mother needs physiological doses of Euthyrox that do not harm the child.

Most often, postpartum thyroiditis goes unnoticed because it clinical manifestations erased, and symptoms such as depression, hair loss and cognitive decline are considered normal for the postpartum period. In some cases, thyroid function recovers on its own and does not require additional treatment.

The thyroid gland is an important component in the metabolic system; the general well-being of a person largely depends on its work. Central Asia, for example, is a specific area where the lack of thyroid hormones affects the growth and mental development of children and adolescents and is associated with water and soil. The most dangerous violation in the work of the thyroid gland in infancy, such babies are very far behind their peers.

In adults - 150 micrograms, in children - from 50 to 120 micrograms, and in pregnant women - 200 micrograms per day. In diseases of the thyroid gland caused by insufficient intake of this microelement in the body, iodine alone is not enough to treat. First, substitution therapy is carried out with a drug containing the hormone itself, for example, the Euthyrox medication. Side effects with such treatment, of course, are possible, but with strict adherence to the dosage, they are minimal.

The drug "Eutiroks", instructions

The drug is a synthetic L-thyroxine, which in therapeutic doses increases the rate metabolic processes, participates in the absorption of fats, proteins and carbohydrates, increases the activity of the nervous and cardiovascular systems. Normalization of thyroxin levels in children and adolescents accelerates their growth, as well as physical and mental development.

The hormonal agent "Eutiroks", the side effects of which are associated with its concentration in the blood, is available in the form of tablets of various dosages (from 25 to 150 micrograms). Such a wide range of doses is due to the fact that the required amount of the drug in children and adults is different. The duration of treatment with the drug "Eutiroks", the dosage and the regimen of administration is determined only by the endocrinologist.

The drug is prescribed for hypothyroidism, benign euthyroid goiter, as a replacement therapy after resection and for thyroid cancer, as well as in combination with other drugs for thyrotoxicosis.

The drug "Eutiroks", side effects

Unpleasant symptoms appear if a large dose of the hormone enters the bloodstream, and all body systems may suffer.

  • Heart: tachycardia, arrhythmia, angina.
  • Nervous system: tremor, agitation, headache, convulsions, fever, weakness, insomnia.
  • Digestion: diarrhea, vomiting, weight loss.
  • hot flashes, menstrual disorders.

After the disappearance of the above symptoms, the drug should be started to drink with minimal doses. It is necessary to consult a doctor if, even after stopping the use of Euthyrox tablets, the side effects continue to bother. Perhaps the diagnosis is wrong and needs to be revised.

The drug "Eutiroks", overdose and contraindications

It is impossible to drink thyroxine with untreated hyperthyroidism, pituitary and cardiac pathologies (heart attack, myocarditis, pancarditis).

During pregnancy with hypothyroidism, the drug is continued continuously. During this period, the combination of the drug "Eutiroks" with thyreostatics in hyperthyroidism is contraindicated, this can provoke thyroid insufficiency in the fetus. During breastfeeding, you need to drink the drug under the supervision of a doctor.

Carefully prescribe a hormonal remedy for heart disease.

Side effects of the drug can be associated not only with an overdose, but also with disturbances in the functioning of the endocrine glands. Before prescribing therapy with Euthyrox, the doctor must exclude thyroid diseases accompanied by increased production of thyroid hormones. If hypothyroidism is due to damage to the pituitary gland, it is necessary to determine whether there is insufficiency of the adrenal cortex. In menopausal women, a large one can lead to osteoporosis, so during this period you need to carefully monitor the work of the thyroid gland and determine the level of its hormones in the blood.

Euthyrox belongs to a group of synthetic hormonal drugs similar to thyroxine (thyroid hormone).

Overdose on it medicine causes severe consequences.

To get a complete picture of the drug, its action and the consequences of an overdose, you need to consider it in more detail.

Community information about the drug

The main active ingredient of Euthyrox is levothyroxine sodium. This synthetic hormone has an active effect on the processes occurring in the human body: tissue growth, metabolism.

Euthyrox is used to compensate for the insufficient production of thyroxine by the human thyroid gland.

In small doses, it can be used for weight correction, due to its positive effect on metabolic processes.

Eutiroks stimulates the synthesis of proteins and fats, which leads to the acceleration of their breakdown and excretion from the body.

At average dosage Euthyrox stimulates work internal organs- Cardiovascular system and digestive tract.

Therapeutic effect

The effect of taking Euthyrox comes after 7 days. If initially diagnosed with low hormonal background(thyroxine deficiency), the effect of therapy occurs after three to five days.

In the treatment of diffuse goiter, a pronounced therapeutic effect is diagnosed only after six months of taking Euthyrox.

After stopping the medication, the hormonal background is restored to normal levels after two weeks. The decay products of the drug are excreted in the urine and bile (through the intestines).

Forms of release of the drug

Euthyrox is available in the form of tablets. Depending on the amount of active ingredient, they may contain from 25 to 150 micrograms of levothyroxine sodium.

Tablets are packaged in blisters (packages with 25.50 or 100 tablets are available).

Indications for use

The appointment of therapy is possible only after a full-time diagnosis by an endocrinologist. Euthyrox is effective in the following diseases:

  • Hypothyroidism (decreased thyroid function);
  • Euthyroid goiter;
  • It is prescribed for prophylactic purposes and for replacement therapy;
  • It provides a replacement for the hormones of the gland in its cancer;
  • The drug is used in thyroid suppression tests to detect disorders in thyroxine production.

Contraindications

There are diseases and conditions in which the use of synthetic thyroid hormones is contraindicated:

  • Reduced pituitary function (without therapy);
  • Increased production of thyroid hormones;
  • Inflammatory processes of the heart muscle and its membranes, myocardial atrophy, acute heart attack;
  • Hypersensitivity to the components of the drug also becomes a contraindication to taking it;
  • Changes in the walls of blood vessels - atherosclerosis, ischemia and disturbances in the heart rhythm, hypertension, become an obstacle to its appointment;
  • Euthyrox should not be prescribed for diabetes mellitus and malabsorption of nutrients.

Causes and manifestations of drug overdose

An overdose of the drug is rare. In order for Eutirox to begin to negatively affect the body, the dose of its intake must be very large.

Symptoms can also be observed with individual intolerance to the main active substance, as well as with a sharp increase in dosage (change of therapy).

An overdose occurs in accordance with the action of the drug.

Since it is similar to thyroid hormones, when it is taken in excess, symptoms similar to hyperthyroidism and acceleration of metabolic processes appear.

Symptoms of an overdose of the drug are as follows:

    • There is a reaction from the cardiovascular system. The pressure rises, angina pectoris, tachycardia are diagnosed. A person may begin to feel an increase in the heartbeat, hear how the heart beats;
    • On the part of the digestive system, pronounced symptoms are noted in the form of vomiting and diarrhea. There is a sharp decrease in weight. Outwardly, he becomes paler, feels weak;
    • In women, an overdose of synthetic hormone causes menstrual irregularities. Menstruation becomes irregular, often painful, excessively abundant or, on the contrary, scanty;
    • On the part of the nervous system, the following negative consequences were revealed in response to Euthyrox. Intracranial hypertension may occur, accompanied by high-intensity headaches. Patients complain of tremor and restlessness. They cannot fully rest due to insomnia, depressive states may develop;
    • Taking Euthyrox at an increased dosage sometimes leads to the development of muscle weakness and muscle pain. If the tolerance threshold is exceeded many times, then severe convulsions, spasms of all muscle groups are observed;
    • Cases of sudden cardiac arrest have been described in those patients who have taken Euthyrox for many years at an excessive dosage.