Memo to the patient: if you are taking L-thyroxine
You have been prescribed (L-thyroxine or Euthyrox, or Bagotirox, or Thyreotom, Thyrocomb, Triiodothyronine, Novotiral, or Levothyroxine sodium of other brands).
There are several important rules taking the drug:
1. L-thyroxine is always taken 20-30 minutes before meals, washed down water(not milk, not juice, not tea or coffee, not sparkling water!!!).
2. If you forgot to take the drug before meals, you can take it 3-4 hours after.
3. In some cases, when a large dose is required, and the drug is not well tolerated, it is allowed to divide the dose 2-3 times a day, that is, 3-4 hours after meals and 30 minutes before the next meal.
4. Some regimens allow you to skip taking L-thyroxine 1 day a week or 2 days a week, but not in a row. The doctor usually talks about this scheme at the appointment. This applies to patients who have a medical history indicating coronary artery disease, arrhythmias, elderly patients (over 75 years old), etc.
5. Don’t try to change the dose yourself! If you feel discomfort while taking the drug, you need to take a blood test for hormones (at least TSH, free T4, free T3) and come to see a doctor. This is especially important for women during pregnancy, when the dose of the drug is important!!!
6. With the selected dose, hormones are monitored, usually 2 times a year. When selecting a dose - once every 2 months.
7. There are regimens in which the dose is changed seasonally (in autumn and winter - the dose is higher, in spring and summer - lower), the regimen is prescribed only by a doctor, and not independently.
8. Most common side effects: palpitations, sweating, irritability, if they do not go away within 10 days, then it is worth discussing with your doctor a change in dose or a change in the regimen of taking the drug.
9. L-thyroxine cannot be combined with the following medications: iron, calcium, antacids (Maalox, Almagel, etc.), the difference between taking these medications should be 4 hours. It is advisable not to mix with other drugs either (minimum interval 15 minutes).
10. During pregnancy, the entire dose of the drug is prescribed immediately; in other conditions, it is selected gradually under the control of hormones! (this is called “dose titration”, the dose is changed once every 1-5 weeks, decided by the doctor).
11. When discontinuing the drug, the entire dose is canceled immediately, without a gradual reduction.
12. Due to surgical intervention or other circumstances, L-thyroxine can be avoided for a maximum of 1 week!
13. Quite rarely, patients experience very high sensitivity to the drug and the dose taken is only 12.5 mcg, 25 mcg or 37.5 mcg; doses higher than this cause a feeling of overdose.
14. It is advisable not to “cut” the drug, but to buy the full dose required for administration, for example, Eutirox is available in doses of 25, 50, 75, 88, 100, 125, 112, 125, 137, 150 mcg! From Germany you can get Eutirox in a dose of 200 mcg, 300 mcg.
15. When taking L-thyroxine during menopause, it is necessary to combine it with taking calcium supplements in a course regimen, under density control bone tissue(densitometry) once every 3-5 years, and for already diagnosed osteoporosis and its treatment - once a year.
16. Taking L-thyroxine is officially approved during pregnancy and lactation.
17. The need for L-thyroxine is greater in children than in adults due to the increased rate metabolic processes, this is due to growth processes.
18. Taking L-thyroxine and at the same time other drugs (such as anticoagulants, COCs, glucocorticoids, prednisolone, etc.) can change the levels of TSH, free T4, free T3, changes in which can only be assessed by a doctor!!!
19. L-thyroxine changes the metabolism in the body (its metabolism changes in relation to the drugs taken) - antidepressants, cardiac glycosides, anticoagulants, some hypoglycemic drugs, anabolic drugs, tamoxifen, furosemide, phenobarbital, carbamazepine, salicylates, amiodarone, somatotropin and some others, Check with your doctor about the effects and dosage of the drug in your case. Do not forget to provide your doctor with a complete list of medications you are taking![U]
20. L-thyroxine is used not only to treat hypothyroidism, but also to treat nodular goiter, diffuse enlargement thyroid gland, in some cases of treatment of DTG, after surgery on the thyroid gland.
21. In the morning, after taking L-thyroxine, you should limit your intake of milk, soy preparations, coffee, and meat.
Thyroxine is an iodine-containing hormone produced by the thyroid gland under the influence of the pituitary gland. thyroid-stimulating hormone. There are many known diseases, the development of which leads to disruption normal operation thyroid gland and, as a result, a decrease in the level of thyroid hormones circulating in the blood. Trying to balance the created imbalance, the pituitary gland “stimulates” the thyroid gland by increasing thyrotropin (TSH), but the latter is not always able to work productively. This is where an endocrinologist comes to the aid of the body with a “magic” tablet of L-thyroxine. Everything is like in a fairy tale: the symptoms slowly but surely pass, and the doctor acquires an aura of holiness and genius in the patient’s eyes. Do you think this is a happy ending? Often this is almost the case, but sometimes, during a follow-up examination some time after the start of treatment, the patient receives the result of a blood test, in which TSH is still elevated. Why this happens, who is to blame and what to do in such a situation will be discussed below.
For reference:
- The thyroid gland produces hormones that control almost all types of metabolism in the body.
- L-thyroxine is obtained synthetically, an absolute analogue of the natural hormone tetraiodothyronine (also known as T4 or thyroxine).
- The half-life of T4 is almost two weeks, the same figure for TSH is 2 months.
- Women suffer from thyroid diseases several times more often than the male half of the population.
Where does treatment begin?
L-thyroxine therapy is designed to externally compensate for the deficiency of thyroid hormones in the human body. However, everyone is different, and this statement applies perfectly to hormone replacement therapy. To select the required dosage for a particular patient, the endocrinologist evaluates many different indicators: test results, height, weight, age, gender, and so on. However, even with the current development of medicine, the dosage of this medicine requires a long selection and clarification, and sometimes this process drags on for several months.
Due to the fact that thyrotropin reacts slowly to the supply of hormones from the outside, the doctor, having prescribed replacement therapy, prescribes the next appointment for the patient after 2-3 months. By this time, the clinical picture will be clear enough to understand whether this dose is suitable for the person or whether there is a need to increase or decrease it. One of the criteria for assessing the effectiveness of treatment is the TSH level, which was initially elevated, and after therapy should decrease.
Repeat visit to an endocrinologist
Before a second appointment with an endocrinologist, you need to re-donate blood for thyroid hormones and thyroid-stimulating hormone (if it is elevated, the doctor will look into it, but more on that below), and depending on what thyroid disease brought you to the doctor, other indicators may be prescribed blood (thyroglobulin, antibodies to thyroid peroxidase, etc.).
If the TSH results are higher than normal, then you should not panic ahead of time. You just need to see your doctor, who will figure out what is causing the problem.
Why didn't TSH decrease?
The reasons why TSH is elevated and does not decrease while taking L-thyroxine can be divided into two groups:
- Due to the patient's fault.
- Due to the medication.
Separately, I highlight the process of dose selection, during which TSH may be higher than normal in several cases:
- The dosage of levothyroxine prescribed is too small.
- The body's need for thyroid hormones has increased due to the progression of the underlying thyroid disease.
Let's take the medicine correctly!
Often, as I already mentioned, TSH is elevated, despite the treatment, due to the fault of the patient himself. Levothyroxine, like any other medicinal substance, has its own application features. Ignoring the instructions for use leads to the fact that it does not have its full effect. Let's discuss the most common patient mistakes that reduce the effectiveness of treatment.
- Preparations containing thyroxine taken in the morning and in one dose! You should not take them at lunchtime, and certainly not before bed. Replacement therapy should imitate the biological rhythms of hormone release in the human body, and normally the largest amount of it is released into the blood in the morning hours.
- Levothyroxine should not be taken with or after food. Only 30 minutes before your planned meal! It cannot be well absorbed in the intestines if the gastrointestinal tract is at this time busy digesting the chop just eaten. Almost half of what you take will not be absorbed, which means the actual amount of medication that your body will receive will be half that which the endocrinologist expected.
- The tablets must be taken daily. Any omission reduces the level of hormones in the blood, which as a result does not allow the doctor, even after 3 months, to adequately assess the quality of the selected dosage, since the already mentioned TSH quickly increases, but is slowly eliminated. As a result, TSH will be elevated in the tests, and it will take you and your doctor even longer to select the correct dose that is right for you.
- Hormonal replacement therapy for diseases of the thyroid gland, courses are NOT carried out. Those. It is not enough to take the medication for a week or a month, it must be taken constantly. After all, when the thyroid gland is functioning properly, it produces hormones every day; therefore, if it is not functioning, then you do its work yourself by taking your morning pill.
For reference:
- Only an endocrinologist can take or change the dose of levothyroxine. It is absolutely unacceptable to independently change the amount of the drug.
- Elevated TSH in women taking this medication may occur during pregnancy.
When is the drug to blame?
Let me clarify right away: the essence of the problem is not in the medicine itself, but in its manufacturer. Unfortunately, counterfeits are not uncommon in our pharmaceutical market. That's what we're talking about. Most counterfeit medications are just dummies, so they will not bring the desired effect. TSH has been elevated and remains elevated, even if you take the drug as described earlier. There is only one solution to this unpleasant situation: buying a new package of the drug. It is better if you purchase an analogue of the drug you are taking at another pharmacy. There are several identical versions of levothyroxine produced by different pharmaceutical companies: Eutirox, Bagotyrox, L-thyroxine, Levothyroxine sodium, Eferox.
How do you know that the dose has been chosen correctly?
Firstly, according to self-feelings. Secondly, your endocrinologist will see characteristic changes in terms of laboratory research. If at the beginning TSH was increased and T4 was decreased, then now both of these indicators should be within the normal range, with minor permissible fluctuations. However, even a correctly selected dose does not cancel scheduled visits to the endocrinologist, at least once every six months.
If your TSH is elevated and your doctor has prescribed you L-thyroxine, read this article to the end. You may find that you do not need this drug. Moreover, if prescribed without reason, L-thyroxine can cause side effects and cause harm to health. I went through this from my own experience and will try to explain everything in simple and understandable language.
L-thyroxine is a synthetic analogue of the thyroid hormone thyroxine, or T4. When might the body need such a pharmacological replacement? Obviously, when the thyroid gland does not produce hormones in the quantities necessary for a healthy and fulfilling life, that is, with a lack of thyroid hormones.
I have no medical education, but I have a thinking head and a three-digit IQ. And this is quite enough to understand that reasons are needed to prescribe L-thyroxine!
Elevated TSH is not a reason to prescribe L-thyroxine. TSH above normal indicates hypothyroidism, but not deficiency thyroid hormones.
If you look closely at my test form, you will be able to find that while TSH is elevated, I do not have a thyroid hormone deficiency. And this is not a rare case - according to data from Dr. Ushakov’s book “Blood Analysis for Thyroid Diseases,” more than 30% of patients with hypothyroidism have a full amount of thyroid hormones in the blood. They may not even realize that they have hypothyroidism until they accidentally end up in an endocrinologist's office (as happened to me).
With elevated TSH, I do not have a deficiency of thyroid hormones
I independently visited a private laboratory and passed full list analyzes “like the first time”, using the recommendations from Dr. Ushakov’s book. If you remove the middle lines from this form, leaving only TSH and anti-TG, any endocrinologist will diagnose you with “hypothyroidism and AIT” and prescribe “treatment” with L-thyroxine. They immediately prescribed me 50 mcg!
Meanwhile, according to Andrei Valerievich’s classification, my condition is called “Small hypothyroidism with compensation” and I do not require any hormone replacement therapy.
Guide for patients “Blood analysis for thyroid diseases”
It's all about compensation ! Here is a definition from the textbook “Blood analysis for thyroid diseases”:
Compensation- this is a state of an organ, system or the entire organism, in which there are enough opportunities to fully ensure functional activity, incl. under unfavorable conditions.
Unfortunately, most doctors completely forget about natural adaptive and compensatory capabilities human body. As they say: “It’s bad when you don’t know, and even forgot!”
So anyway elevated TSH they “see” a lack of thyroid hormones. Treatment - L-thyroxine. They can still prescribe a lot of Iodomarin.
And again we turn to the textbook:
If a blood test reveals T4F values. and T3st. at optimum, then the introduction of additional amounts of the same hormones with the drug is usually not necessary, regardless of the amount of TSH.
According to Dr. Ushakov, the middle 50% of the reference interval corresponds to the optimum.
But what to do in a situation where the values of T4sv. and T3st. Are they in the first 25% of the reference interval or are they generally below normal?
Here we need to introduce you to the concepts of subcompensation and decompensation. It will be easier for you if you draw a segment on a piece of paper that will display the reference interval of your laboratory and divide it into four equal parts. The first part of the segment will correspond to the first 25% of the reference interval. If your T4sv values. and T3st. fall into this interval, this indicates a subcompensatory amount of thyroid hormones. Dr. Ushakov characterizes this condition as an incipient hormone deficiency (with TSH>10).
In this condition, you need to start as soon as possible rehabilitation treatment, aimed at the basis of the disease. But most doctors prescribe L-thyroxine, and not in small doses, but in medium ones (50-75 mcg).
Condition when TSH>10 and T4s. and T3st. less than normal is called “moderate hypothyroidism with thyroid decompensation.” In this case, taking L-thyroxine in small and medium doses is indicated.
You need to understand what role L-thyroxine plays in these cases. Only auxiliary! It only supports functional processes, but does not lead to recovery.
1. Request a blood test for thyroid hormone levels; a full analysis includes indicators of TSH, T3f, T4f, T3tot, T4tot, anti-TPO and anti-TG;
2. Request justification for the prescription of the hormonal drug in the medical document;
3. If the doctor cannot explain to you why he prescribes L-thyroxine or is guided only by the TSH indicator, take it necessary tests yourself and decipher them using the textbook for patients “Blood Analysis for Thyroid Diseases” by Dr. Ushakov.
If restorative treatment is not carried out, the patient is forced to take L-thyroxine throughout his life in order to maintain sufficient hormone levels. This is convenient for an illiterate doctor, but not very good for the patient.
With auxiliary actions, the structure of the organ (body part, system) does not improve. Moreover, any replacement contributes to the corresponding restructuring in the body. One of the aspects of such an adaptation is a decrease in the structural composition of the organ (in this case, the thyroid gland) and its functional abilities.
Let me put it simply: if a doctor “puts you on” to L-thyroxine and does not provide restorative treatment aimed at the basis of the disease, then by these actions he harms you. The longer you take L-thyroxine, the more the amount of thyroid tissue and its compensatory capabilities decrease. And the more difficult it will be for a competent doctor to “take you off” L-thyroxine. But nothing is impossible - just look at the results of Dr. Ushakov’s patients. L-thyroxine can be discontinued.
Ideally, a competent physician should aim to manage treatment in a manner that gradually reduces the dose and eventually eliminates hormone replacement therapy.
You probably have a question: “What is restorative treatment? What is it aimed at? In general, I want to tell you that in modern medicine“treatment” means any medical manipulation. Often such actions cause side effects, cause harm and even lead to disability. Official medicine in its current form is not capable of leading the patient to a complete recovery. Doctors do not have a cure for hypothyroidism and AIT.
And it seems that there is no way out of this endocrinological impasse unless one takes into account one fact: the body of every person contains natural self-healing mechanisms. We just need to hear what the body wants to tell us with its condition. You need to understand the essence of hypothyroidism and AIT, why the body behaves this way, why TSH increases and antibodies are produced. I began to guess a lot when, with a change in living conditions to more favorable ones, my hypothyroidism symptoms completely disappeared. Later, I found confirmation of my guesses in the books of Dr. Ushakov - so far the only doctor in Russia who actually treats his patients and does not “addict” them to TSH.
Rehabilitation treatment- this is the creation of favorable conditions for the body’s self-healing. It may include a whole range of measures: a change in lifestyle, a transition to healthy eating, active recreation, physiotherapy, massage, etc.
I know that this sounds like “general words” and “no specifics” to you. It’s hard to believe in the possibility of regeneration of the thyroid gland and I want a “magic pill” that will remove all symptoms. And it's even harder to admit that you're doing something wrong in your life - working too much in a stressful job, eating too much junk food, you spend too little time in the fresh air.
If this is the case, then I advise you to read both books by Dr. Ushakov - “Restoration of the Thyroid Gland” and “Blood Analysis for Thyroid Diseases”, and then look at the results of his patients (confirmed laboratory tests and ultrasound).
Website of the book “Blood analysis for thyroid diseases”:
Name: Irina, Lugansk
Question: If the TSH result is 0.04 El-thyroxine should the dosage be increased or decreased?
Answer:
Thyroid-stimulating hormone is a substance produced by the pituitary gland and has the function of regulating triiodothyronine (T3) and.
Some hormonal imbalances require hormone replacement therapy to restore normal synthesis of substances.
TSH, together with hormones along with T3 and T4, has the following effects on the body:
- activates the production of hormones;
- stimulates metabolic processes;
- participates in heat exchange;
- improves synthesis nucleic acids and phospholipids;
- promotes glucose production;
- regulates the synthesis of red blood cells;
- increases iodine consumption by thyroid cells.
At various pathologies and dysfunction of the glandular organ, hormonal imbalance may occur.
To stabilize it, doctors prescribe hormonal drugs, and most often - L-thyroxine.
Thyroxine in medication, as the main one active substance is a synthetic hormone that supports the functioning of the thyroid gland.
The active component, entering the kidneys and liver, is partially converted into triiodothyronine, promoting tissue development and growth.
L-thyroxine is prescribed for the following diseases:
- benign thyroid formations;
- hyperthyroidism;
- diffuse goiters;
- thyroid cancer;
- after resection of the thyroid gland.
That is, the range of drug prescriptions is quite wide.
That is why L-thyroxine, its dosage and dosage regimen can be prescribed exclusively by the attending physician, based on medical history and clinical picture, and only during a face-to-face consultation.
Independent uncontrolled use medicine can lead to serious consequences.
I can say that for women normal indicator a level of 0.3 to 4.2 µIU/ml is considered.
If the thyroid gland has been removed, then this figure can reach 5 µIU/ml.
Your parameter reaches lower limit norms, but still there are no deviations.
If you are concerned about any symptoms, I recommend that you consult an endocrinologist.
L-thyroxine reduces TSH production. That is, if you increase the dose, then TSH will decrease, and if you decrease it, then, accordingly, it will increase.
L-thyroxine is pharmacological drug, an analogue of thyroid hormones. It is prescribed to patients with reduced function of this organ for compensation and stabilization hormonal levels. An overdose of L-thyroxine can occur in patients if they do not comply with the treatment regimen prescribed by the doctor.. To avoid symptoms of overdose, it is necessary to accurately calculate the amount of substance taken, taking into account the weight, age and degree of pathology of the patient. Increasing the dosage for therapeutic purposes in persons taking the drug for the first time leads to the development of signs of intoxication.
The drug is prescribed for hypothyroidism, sick after surgical removal thyroid gland, after treatment radioactive iodine.
L-thyroxine, depending on the dose, has different effects on the human body. Lack of thyroxine enhances the anabolic effect (increases protein synthesis, promotes growth muscle tissue). Its presence activates the cardiovascular system and stimulates nervous activity. The substance is capable of accelerating the breakdown of proteins, fats and carbohydrates, thereby causing an increased need for oxygen in cells.
Overdose symptoms
Taking L-thyroxine in doses exceeding the norm leads to disruption of physiological processes in the body, failure of organs and systems. With an excess amount of thyroid-stimulating hormone (TSH) in the body the synthesis of biologically increases sharply active substances , metabolic processes are accelerated.
Thyroxine primarily affects cardiovascular system. The following symptoms are observed: 
- Increased heart rate;
- Tachycardia (rapid heartbeat);
- Atrial fibrillation (irregular heart rhythm);
- Thromboembolism (blockage of blood vessels with blood clots);
- Angina attack.
- Myocardial infarction, including microinfarctions;
- Angina;
- Atherosclerosis;
- Coronary heart disease (CHD);
- Coronary circulatory insufficiency;
- Severe form of hypertension;
- Organic damage to the structures of the heart (pericarditis, myocarditis).
Symptoms of mild overdose
Depending on age and general condition person, the first signs of intoxication may appear in the coming hours after taking the medicine or in a few days.
Manifestations: 
- Digestive system ─ disorders of digestion and absorption of food, diarrhea, aching pain in the intestines, heaviness in the epigastric region, loss of appetite;
- Cardiovascular system ─ frequent heartbeat and pulse;
- Nervous system ─ sleep disturbance, increased sweating, feeling tired;
- Psyche ─ motor restlessness, speech agitation, feelings of anxiety and fear, tremor of the limbs (trembling);
- Slight increase in body temperature;
- Allergic reactions.
These signs are also characteristic of chronic poisoning.
Symptoms of chronic overdose
Chronic poisoning develops in people who are forced to take the hormone for a long time. Symptoms are similar in appearance to thyrotoxicosis.
Clinical manifestations: 
- Weight loss with normal appetite and calorie intake;
- Metabolic disorders;
- Vomiting and abdominal pain;
- Frequent urination;
- High systolic and low diastolic pressure;
- Nervous excitability, sudden mood changes;
- Memory impairment, voice timbre;
- Difficulty swallowing;
Symptoms of acute overdose
Acute poisoning of the body occurs when taking thyroxine in large quantities when a substance acts as a poison to the body.
Symptoms appear on the first day. Man feels severe pain in the region of the heart, hot flashes. Against the background of nervous excitement, severe muscle weakness is felt. The use of high doses of thyroxine leads to respiratory, renal failure, and myocardial infarction.
The most serious side effect An overdose of thyroxine is a thyrotoxic crisis, which is characterized by a rapid increase in all signs of thyrotoxicosis. Observed mental disorders in the form of a disturbance of consciousness ─ delirium, insanity. A person may be in a semi-fainting state, which leads to the development of coma.
Symptoms of the onset of thyrotoxic crisis:
- Temperature rises to 40-41°;
- Vomiting and diarrhea;
- Apathy and prostration;
- Increased blood pressure;
- The amount of urine excreted decreases, leading to anuria.
The condition is getting worse acute process liver atrophy. Excitement is replaced by stupor, then loss of consciousness followed by a transition to coma.
The lethal dose of El-thyroxine has not been established. The body’s reaction to a particular amount of a substance depends on the person’s body weight and the physical strength of the body.
Overdose of L-thyroxine in pregnant women and children
Pregnancy is not an obstacle to taking the hormone thyroxine. The drug does not affect the embryo in the first trimester of pregnancy and does not cause gene mutations. Even when the mother consumes large doses, the child is not subject to any influence, since this is prevented by the placental barrier. Hormone in breast milk is contained in small doses and is not enough to cause any physiological disturbances in the child.
In children, taking the medicine may cause tremors in the limbs. Prescribing should be cautious if the child suffers from epilepsy or is prone to seizures. In this case, thyroxine will intensify the symptoms and worsen the general condition.
Diagnostics
To recognize an overdose and determine the severity of poisoning, carry out tests to assess the production of thyroid-stimulating hormone. With a high level of the hormone thyroxine in the blood, there is a discrepancy between the serum concentration of hormones and clinical manifestations.
A venous blood sample of 5 ml is taken from the victim to test for thyroid hormones (TSH, T3, T4). In this case, the results will always show increased thyroxine (T4) and triiodothyronine (T3), as well as decreased thyroid-stimulating hormone.
Medical assistance in case of drug overdose
What should I do if my condition begins to noticeably worsen after taking the medicine? If a person feels unwell, weak or any other symptoms that have not previously appeared, you should consult a doctor. If you feel satisfactory, you should come to the clinic for an appointment or call a doctor at home. If the condition worsens sharply, you should immediately call an ambulance.
In what cases is there a need for urgent medical intervention: 
- The child was injured old man, pregnant woman;
- Severe pain in the heart, irregular heart rhythm;
- High blood pressure;
- Profuse diarrhea mixed with blood;
- Neurological pathology ─ paresis, paralysis, convulsions;
- A depressed state in which a person does not respond to external stimuli;
- Unconscious state.
There is no specific antidote to L-thyroxine. Therefore, help lies in eliminating the symptoms of poisoning. Depending on the severity of intoxication, a person can be treated at home or in a hospital, in the endocrine department.
Symptomatic drug therapy:
- To restore heart rhythm, adrenergic blockers are prescribed (increase sympathetic tone);
- At nervous disorders─ sedatives;
- At high blood pressure─ antihypertensive drugs;
- To reduce temperature ─ antipyretics.
Neuroleptics should absolutely not be used as sedatives. They will intensify the symptoms of thyrotoxicosis and increase the risk of developing arrhythmia. To suppress the effect of large doses of thyroxine, glucocorticosteroids are prescribed.
In severe cases, hemosorption is performed - purification of the blood from poison and toxic substances. This procedure is used in patients in the stage of unconsciousness or coma. The blood passes through a special apparatus, where it reacts with the sorbent and is thus purified.
Another blood purification procedure is plasmaphoresis. The victim is connected to a special device, and a certain volume of blood is pumped through it. In this case, plasma containing large number thyroxine is separated, and the remaining components return to the bloodstream.
Emergency care for acute overdose of thyroxine at home
It is advisable to carry out urgent assistance only if symptoms arose immediately after taking the drug, as well as in the case of rapid detection of suicide, when a person took a large dose once.
Resuscitation measures should be carried out if no more than 30-40 minutes have passed since the use of the substance: 
- Perform gastric lavage. Allow the victim to drink 3-4 glasses of water in a short time interval. Then induce artificial vomiting. To do this, press on the root of the tongue with two fingers;
- Take any of the sorbents that are in your home medicine cabinet ─ activated carbon, Polysorb, Enterosgel, Polyphepan;
- Take a saline laxative ─ sodium chlorine, magnesium sulfate, saline solution (a tablespoon of salt in half a glass of water). Such solutions retain water in the intestines and increase its volume. As a result, its contents soften and are then quickly and easily removed from the body.
Consequences and complications of thyroxine overdose
Common complications include:
- Angina;
- Bronchial spasm;
- Decreased production of pituitary hormones, which regulate the functioning of the thyroid gland;
- Hyperthyroidism;
- Osteoporosis.
Less commonly encountered serious allergic manifestations: Quincke's edema, bronchial asthma, lupus erythematosus.
To avoid possible overdose, the treatment regimen should be followed. If the first signs of intoxication appear, the doctor is obliged to examine the patient and reduce the single dose of the drug.