Temporomandibular dysfunction jaw joint(TMJ) is associated with changes in the jaw, jaw joint, and surrounding facial muscles involved in chewing and jaw movements.


Causes of dysfunction of the temporomandibular joint:

Causes of temporomandibular dysfunction mandibular joint not fully elucidated, however, dentists suggest that this problem is associated with violations on the part of jaw muscles or elements of the joint itself.

The active substance is zoledronic acid. Each 100 ml solution in a sachet contains 5 mg of anhydrous zoledronic acid. One milliliter of solution contains 0.05 mg anhydrous zoledronic acid. The other ingredients are sodium dihydrate, sodium hydroxide for regulation, hydrochloric acid for regulation, and water for injection.

Supplied in one bag. Ingredients: methotrexate. The Methotrexate Agreement Contains Methotrexate active substance. Methotrexate is a cytotoxic drug that inhibits cell growth. Methotrexate has the strongest effect on cells that multiply rapidly, such as cancer cells, bone marrow cells, and skin cells.

Temporomandibular joint dysfunction can result from trauma to the jaw, temporomandibular joint, or head and neck muscles, such as from a violent blow or whiplash. To others possible reasons relate:
Bruxism or clenching of teeth, leading to an overload of the temporomandibular joint;
Displacement of the intra-articular cartilaginous disc located between the head of the joint and the articular fossa;
Damage to the temporomandibular joint due to osteoarthritis or;
Stress, the result of which is a tendency to tighten the facial or jaw muscles or clench your teeth.

Methotrexate Accord is used to treat these types of cancer. Acute lymphoblastic leukemia; prevention of meningeal leukemia; non-Hodgkin's lymphoma; osteogenic sarcoma; adjuvant therapy and advanced breast cancer; metastatic or recurrent head and neck cancer; choriocarcinoma and related trophoblast diseases; widespread cancer Bladder. Methotrexate Accord should not be vaccinated with a live vaccine during treatment.

Methotrexate can cause serious and sometimes life-threatening side effects. Your doctor will discuss the benefits and risks of treatment with you and what are the early signs and symptoms of unwanted effects. Therefore, it is necessary to avoid sunlight and solarium; Methotrexate can lead to a decrease in the immune system, oxygen-carrying and cells needed for normal blood clotting, which increases the risk of infection or increased bleeding. Methotrexate has been shown to cause fetal death and birth defects. . Talk to your doctor, pharmacist, or nurse before taking methotrexate.


Symptoms of dysfunction of the temporomandibular joint:

Symptoms of temporomandibular joint dysfunction can be severe pain and discomfort, which may be temporary or persist for many years. Temporomandibular joint dysfunction is most often observed in the age group from 20 to 40 years (women get sick more often than men).

Together, the risk of tissue and bone loss may increase; When injected into the spinal cord or vein, it can lead to life-threatening inflammation of the brain; if you have symptoms associated with a condition in which fluid accumulates in the body, such as in the lungs or in the abdomen; if you have impaired renal function; if you have impaired liver function; if you have an infection; if necessary for vaccination. Methotrexate consent may reduce the effectiveness of vaccines; If you are insulin dependent diabetes, your condition should be carefully monitored during treatment with methotrexate. If you are taking radiation therapy with methotrexate. . Recommended precautions and precautions.

Typical symptoms of TMJ dysfunction are:
Pain or tenderness in the face, jaw joints, neck and shoulders, in or near the ear when chewing, talking, or opening the mouth wide
Limiting the amplitude of opening the mouth
Blocking ("jamming") of the jaw in an open or closed position
Clicking, popping or grinding in the jaw joint when opening and closing the mouth (sometimes accompanied by pain).
Fatigue of the facial muscles
Difficulty chewing or sudden “uncomfortable” bite (feeling that the upper and lower teeth do not meet correctly).
Puffiness on one side of the face

Methotrexate can cause serious side effects even when used in low doses. Your doctor needs to check and laboratory tests to see these effects in a timely manner. Before starting treatment, your doctor may do blood tests and check your kidneys and liver. You may need to take an x-ray chest. Further research may be done during or after your treatment. Don't miss visiting blood tests.

Other medicines and methotrexate Talk to your doctor or pharmacist if you are taking or have recently taken any other medicines, or if you are unsure. Vitamin preparations containing folic acid or substances similar to folic acid. Medicines for rheumatism. Medicines to lower high blood pressure. Medicines for the treatment of gout. radiation therapy. Medicines for the treatment of stomach ulcers, scarring, reflux. Medicines for the treatment of epilepsy. Medicines to treat psoriasis or severe acne. Medicines to treat rheumatoid arthritis or intestinal diseases. Medicines for the treatment of organ transplantation after transplantation. Vaccination with a live vaccine.

  • Pain medication.
  • Cancer treatment.
  • Preparations for the treatment of infectious diseases.
  • Medicines for the treatment of asthma.
Taking methotrexate Accord with food, drink and alcohol.

Other common symptoms are toothache or earache, hearing loss, upper shoulder pain, and ringing in the ears (tinnitus).


Diagnostics:

Symptoms of temporomandibular joint dysfunction may resemble those of many other conditions (dental or sinus problems, inflammatory diseases gums), so your doctor will take a thorough history and conduct a clinical examination to determine the cause of your symptoms.

Do not drink alcohol while taking methotrexate and avoid a large number coffee, soft drinks containing caffeine or black tea. Pregnancy, breast-feeding and fertility. If you are pregnant, breastfeeding, think you are pregnant or are planning to become pregnant, talk to your doctor before taking this medicine.

Methotrexate has been reported to cause fetal death and birth defects. Therefore, methotrexate-consent should not be used during pregnancy unless directed to do so by a doctor. If you think you are pregnant, tell your doctor immediately. If you are being treated or your partner is being treated with methotrexate, you must be careful not to suffer because both the woman and the man may be affected by the treatment. It is not known how long you or your partner need to stop treatment before trying to get pregnant.

The doctor will check the temporomandibular joint for pain or tenderness; listen to sounds in the joint (are there any clicks, crackles or grinding sounds during jaw movements); will pay attention to the limitation of range of motion or "jamming" of the jaw when opening or closing the mouth; evaluate the type of bite and the function of the facial muscles. Sometimes it is necessary to take a panoramic x-ray (a full-face x-ray in which the doctor can see both jaws, the TMJ, and all teeth at the same time, which allows you to exclude other causes of the observed symptoms). In some cases, magnetic resonance imaging (MRI) or computed tomography (CT) is required. MRI can image soft tissues, such as the intra-articular TMJ disc, which allows you to check the correct position of its position during jaw movements. CT scanning makes it possible to examine the bone structure of the joint.

Various recommendations are offered, ranging from three months to one year. Methotrexate is excreted in human milk in amounts that may be harmful to the baby. Therefore, breastfeeding should be discontinued during treatment with methotrexate. Undesirable effects are possible: fatigue and dizziness. If you feel tired or dizzy, do not drive or operate machinery.

This should be considered by patients who restrict their sodium intake. food products. How to take methotrexate agreement. Methotrexate agreement is a healthcare professional. The dose and frequency of use of the dose depends on the treatment, health status and age, body weight and body surface area. Methotrexate Accord can be injected into muscles, veins, arteries, and spinal cord.

Based on the results of the examination, the doctor may decide to refer you for further observation and treatment to a dental surgeon (maxillofacial surgeon). This is a narrow profile doctor specializing in surgical interventions in the face, jaw and oral cavity.


Treatment of dysfunction of the temporomandibular joint:

Treatment options can range from simple recommendations for caring for the affected joint area and applying conservative methods before injections and surgery. Most experts believe that treatment should begin with conservative (non-surgical) measures, resorting to surgery only in extreme cases. Many of the methods listed below give best effect with combined use.
Applying moist heat or cold compresses. A cold compress is applied for 10 minutes. to the corresponding side of the face and temple area.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist. Methotrexate compliance can cause unwanted effects that can be dangerous and even life-threatening. During treatment, you should watch for signs of unwanted effects and inform your doctor. Call your doctor right away if you notice any of the following side effects. You may need urgent medical attention.

Sudden onset of itching skin rash, swelling of the hands, feet, ankles, face, lips, or throat. Fever, chills, body pain and sore throat. Unexplained bleeding or unexplained bruising, black, tartan-like stools.

  • Unexplained shortness of breath, dry cough or wheezing.
  • Also, you may feel like you will leave immediately.
  • Vomiting, diarrhea or stomatitis and peptic ulcer.
  • Dizziness of the skin and eyes, dark urine.
List adverse reactions registered during treatment with methotrexate, is presented below depending on the frequency of violations.

Then they perform a few simple exercises to warm up the jaw muscles recommended by a dentist or exercise therapy specialist. After doing the exercises, apply a warm towel or napkin to the affected side of the face. These procedures are repeated several times a day.
Exclusion of solid food. The food includes foods with a soft texture (yogurt, mashed potatoes, cottage cheese, soups, omelettes, fish, cereals, boiled fruits, vegetables and legumes). Foods are cut into small pieces before consumption to reduce the need for chewing. Exclude hard and crunchy foods (buns with a hard crust, dried, raw carrots), foods that require long chewing (caramel, toffee), as well as large pieces of food and fruits that are bitten off with a wide-open mouth.
Reception medicines. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen (Advil, Motril, Aleve), available over the counter, can be used to relieve pain and swelling. Your doctor may recommend higher doses of these or other NSAIDs or prescribe a different medication, such as narcotic analgesic. Muscle relaxants may be prescribed to relieve tension in the jaw muscles (especially with bruxism or the habit of clenching the teeth). To reduce stress (which in some cases is regarded as an aggravating factor in TMJ dysfunction), sedatives can be used. Removal or relief of pain is also facilitated by taking small doses of antidepressants. Muscle relaxants, sedatives and antidepressants are available only by prescription.
Low frequency laser treatment. Used to relieve pain and inflammation, as well as to increase range of motion in cervical region and amplitude of mouth opening.
Wearing an orthopedic tire (splint) or cap. A splint and a dental cap are plastic nozzles that are worn on the upper and lower teeth. They prevent teeth from closing, which reduces Negative consequences from clenching or grinding of teeth. In addition, they contribute to the correction of the bite, keeping the teeth in the most correct and least traumatic position. The main difference between a splint and a mouthguard is that a mouthguard is worn only at night, while a splint is worn all the time. If you need a mouth guard, your doctor will discuss with you what type of mouth guard you need.
Orthopedic and orthodontic treatment. Replacement of missing teeth, installation of crowns, bridges or braces to align the cutting surfaces of the teeth or correct the bite.
Limitation of joint movement. It is recommended to yawn as little as possible and to minimize chewing movements (especially the use chewing gum and ice cream), as well as avoiding maximum joint movements (as in screaming and singing).
It is not recommended to rest your chin with your palm or hold the handset between your shoulder and ear. Correct posture helps to relieve pain in the cervicofacial region.
To reduce jaw tension, keep your mouth slightly open as much as possible. AT daytime Putting the tip of the tongue between the teeth helps prevent clenching or grinding of teeth.
Learning relaxation techniques helps to reduce jaw muscle tension. Talk to your dentist about the need physiotherapy exercises or massage. Consider using stress relief techniques such as biofeedback (BFB).

Often. Loss of appetite, nausea, vomiting, abdominal pain, indigestion, dyspepsia. Rash, redness and itching.

  • Inflammation and ulceration of the mouth and throat.
  • Improved liver enzymes.
  • Thyroid hernia.
  • Blood effects, for example: anemia, leukocytopenia, thrombocytopenia.
  • Headache, fatigue, drowsiness.
  • Dry cough, shortness of breath, chest pain, fever.
  • Diarrhea.
Rare.

Visual impairment, blurred vision. Thrombosis. Low blood pressure. sore throat, sleep apnea, bronchial asthma. Gout inflammation. Ignition small intestine. Bloody stool. Malabsorption. Liver damage. Acne, skin ulcers, changes in nail pigmentation, blueberries. Fractures. Renal failure, oliguria, azotemia and anuria. An increase in the level of uric acid in the blood. Elevated serum creatinine and urea. Abnormal breast enlargement. Enhanced level blood sugar.

  • Pericarditis, pericardial fluid and cardiac tamponade.
  • Megaloblastic anemia Mood changes.
  • Effects on language, including articular speech disorder and inability to speak.
  • Bone marrow disorder.
Very rarely.